| Rookie | Injured | Injured rookie |
| WR | 83 Mark Bradley | 17 Lance Long | 10 Terrance Copper | ||||
|---|---|---|---|---|---|---|---|
| LT | 76 Branden Albert | 74 Wade Smith | 67 Barry Richardson | ||||
| LG | 54 Brian Waters | 74 Wade Smith | |||||
| C | 64 Rudy Niswanger | 74 Wade Smith | |||||
| RG | 62 Andy Alleman | 60 Ikechuku Ndukwe | |||||
| RT | 75 Ryan O'Callaghan | 60 Ikechuku Ndukwe | |||||
| TE | 45 Leonard Pope | 89 Sean Ryan | 87 Brad Cottam | 85 Jake O'Connell | |||
| WR | 11 Chris Chambers | 80 Bobby Wade | |||||
| QB | 7 Matt Cassel | 12 Brodie Croyle | 15 Matt Gutierrez | ||||
| FB | 42 Mike Cox | 46 Tim Castille | |||||
| RB | 25 Jamaal Charles | 21 Kolby Smith | 29 Dantrell Savage |
| LE | 94 Tyson Jackson | 92 Wallace Gilberry | |||||
|---|---|---|---|---|---|---|---|
| NT | 95 Ron Edwards | 90 Kenny Smith | |||||
| RE | 72 Glenn Dorsey | 92 Wallace Gilberry | 71 Alex Magee | ||||
| LOLB | 50 Mike Vrabel | 96 Andy Studebaker | 55 Justin Rogers | ||||
| LILB | 53 Demorrio Williams | 56 Derrick Johnson | 52 David Herron | ||||
| RILB | 51 Corey Mays | 59 Jovan Belcher | |||||
| ROLB | 91 Tamba Hali | 97 Pierre Walters | |||||
| LCB | 24 Brandon Flowers | 31 Maurice Leggett | 34 Travis Daniels | ||||
| RCB | 39 Brandon Carr | 23 Mike Richardson | 20 Donald Washington | ||||
| SS | 30 Mike Brown | 31 Maurice Leggett | |||||
| FS | 47 Jon McGraw | 31 Maurice Leggett | 38 DaJuan Morgan |
| P | 2 Dustin Colquitt | ||||||
|---|---|---|---|---|---|---|---|
| K | 6 Ryan Succop | ||||||
| KO | 6 Ryan Succop | ||||||
| PC | 43 Thomas Gafford | 96 Andy Studebaker | |||||
| KC | 43 Thomas Gafford | ||||||
| H | 2 Dustin Colquitt | ||||||
| PR | 80 Bobby Wade | 29 Dantrell Savage | 31 Maurice Leggett | ||||
| KR | 25 Jamaal Charles | 29 Dantrell Savage |